Tranexamic acid is widely recommended to reduce blood loss in major joint arthroplasty, but optimal dosing remains unclear—especially in patients with chronic kidney disease. A new personalized dosing regimen, developed by Qi Yang, PhD, uses pharmacokinetic modeling to tailor treatment based on weight and kidney function.

Malignant hyperthermia (MH) is a rare but potentially fatal complication triggered by inhalational anesthetics and succinylcholine in genetically susceptible ICU patients. This expert-led review by Sheila Riazi, Teeda Pinyavat, and Jia Wen Deng provides essential guidance on recognizing and managing MH in critical care. Learn how to identify symptoms early and implement life-saving treatment protocols in the ICU.