A phase IV randomised, controlled, implementation trial of volatile based sedation in patients with COVID 19 (the ANACONDA study)
This is a transformative project which provides evidence of the benefits of inhaled volatile anesthetics for the sedation of ventilated COVID 19 ICU patients. The 50-patient pilot trial funded by the Innovation Fund demonstrated the feasibility and potential efficacy of this original concept for theses critically ill patients. Particularly when the availability of intravenous sedative medication was limited in early days of the pandemic, the use of inhaled anesthetics was found to be feasible (with a multidisciplinary group), accelerated awakening and reduced lung inflammation. The project has generated considerable attention internationally and resulted in the funding of a national randomized trial (SAVE-ICU). Many centres around the world have followed the process established by the Sunnybrook investigators to deliver volatile anesthetics for sedation during COVID necessitated ventilation. Active sub-studies include cost effectiveness, cognition and biomarkers.
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